𝔖 Bobbio Scriptorium
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Strategies for transcriptional activation by steroid/nuclear receptors

✍ Scribed by Leonard P. Freedman

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
167 KB
Volume
75
Category
Article
ISSN
0730-2312

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✦ Synopsis

Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone-modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters.

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