𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechanisms of transcriptional activation by steroid hormone receptors

✍ Scribed by Aria Baniahmad; Ming-Jer Tsai

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
547 KB
Volume
51
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Steroid hormones are involved in cell growth, development, and differentiation. The hormonal signal is mediated by nuclear receptors which represent a specific class of transcription factors. During the last few years, the cloning of all the major steroid hormone receptors increased our insight into how the hormonal signal converts the receptor into a transcriptional activator. Good progress has been made towards understanding the mechanism of steroid hormone action. In this review we will discuss the role of heat shock proteins in the process of transcriptional activation, the mechanistic differences between the hormone (agonist) and the antihormone (antagonist), the resulting functional consequences, and a possible mode by which transcriptional activation is mediated.

πŸ“œ SIMILAR VOLUMES

Strategies for transcriptional activatio
Strategies for transcriptional activation by steroid/nuclear receptors
✍ Leonard P. Freedman πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 167 KB

Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histon

Steroid hormone receptors and In vitro t
Steroid hormone receptors and In vitro transcription
✍ George F. Allan; Sophia Y. Tsai; Bert W. O'Malley; Ming-Jer Tsai πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 763 KB

Steroid hormone receptors are ligand-inducible transcription factors that exhibit potent effect on gene expression in living cells. Precise dissection of their mode of action at the molecular level can best be carried out in functional cell-free systems. This article will describe the benefits of su

Oligodeoxynucleotide base recognition by
Oligodeoxynucleotide base recognition by steroid hormone receptors
✍ S. Anand Kumar; Thaisa A. Beach; Herbert W. Dickerman πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 580 KB

Oligodeoxynucleotides covalently linked to cellulose were used as probes of the DNA-binding domains of mouse steroid holoreceptors. With uterine cytosol estrogen receptor (E2R) the relative binding order, in prior studies, was oligo(dG) > oligo(dT) 2 oligo(dC) > > oligo(dA) > oligo(d1). The binding