Straightforward Ring Expansion of Pyroglutamates to Perhydro-1,3-diazepine-2,4-diones
✍ Scribed by Stevens, Christian V.; Dieltiens, Nicolai; Claeys, Diederica D.
- Book ID
- 127086282
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 49 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
The solid phase synthesis of 1,3,4,7-Tetrasubstituted Perhydro-l,4-diazepine-2,5-diones is described. Starting from the resin-bound tBu ester ofaspartic acid and employing reductive alkylation and
## Abstract Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones was accomplished starting from 4‐amino‐3‐(4‐chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3‐(4‐chlorophenyl)‐4‐ureidobutyric acids. However, none of the new derivatives
## Abstract The structures of the previously reported aryl‐perhydro‐1,3‐diazepine‐2,4‐diones are shown to be pyrro‐lidinone carboxamide derivatives by nmr spectroscopy.