## Abstract The interferon‐inducer, polyinosinate. Polycyctidylate [Poly (I). Poly (C)] stimulated both prostaglandin E (PGE) and hyaluronic acid (HA) production by human cultured synovial fibroblasts. Increased accumulation of PGE in the medium was noted within 3 hours of culture, while accumulati
✦ LIBER ✦
Stimulation of prostaglandin E production in cultured human fibroblasts by poly(I) · poly(C) and human interferon
✍ Scribed by GURARI-ROTMAN, D.; REVEL, M.; LINDNER, H. R.; ZOR, U.; YARON, M.; YARON, I.
- Book ID
- 109705035
- Publisher
- Nature Publishing Group
- Year
- 1977
- Tongue
- English
- Weight
- 321 KB
- Volume
- 267
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/267457a0
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The authors have shown that the interferon inducer, double-stranded polynucleotide, poly I poly C, and human interferon stimulate prostaglandin E (PGE) (1) and hyaluronic acid (HA) production (2) in human synovial fibroblast cultures and induce inflammation when injected into the rat joint ( 3 ) . A