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Stimulation of prostaglandin e production by bacterial endotoxins in cultured human synovial fibroblasts

✍ Scribed by Michael Yaron; Ilana Yaron; Ophyra Smetana; Emanuel Eylan; Uriel Zor

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
379 KB
Volume
23
Category
Article
ISSN
0004-3591

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The authors have shown that the interferon inducer, double-stranded polynucleotide, poly I poly C, and human interferon stimulate prostaglandin E (PGE) (1) and hyaluronic acid (HA) production (2) in human synovial fibroblast cultures and induce inflammation when injected into the rat joint ( 3 ) . A

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## Abstract The interferon‐inducer, polyinosinate. Polycyctidylate [Poly (I). Poly (C)] stimulated both prostaglandin E (PGE) and hyaluronic acid (HA) production by human cultured synovial fibroblasts. Increased accumulation of PGE in the medium was noted within 3 hours of culture, while accumulati