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RNA and DNA Viral Stimulation of Prostaglandin E Production by Human Synovial Fibroblasts

✍ Scribed by Michael Yaron; Ilana Yaron; Dan Caspi; Ophyra Smetana; Emanuel Eylan; Uriel Zor

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
393 KB
Volume
24
Category
Article
ISSN
0004-3591

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✦ Synopsis

The authors have shown that the interferon inducer, double-stranded polynucleotide, poly I poly C, and human interferon stimulate prostaglandin E (PGE) (1) and hyaluronic acid (HA) production (2) in human synovial fibroblast cultures and induce inflammation when injected into the rat joint ( 3 ) . A possible relationship between viral infection and connective tissue diseases has been repeatedly suggested (4). The purpose of the present study was to further evaluate the possibility that prostaglandin E may be a mediator of the inflammatory process induced by viruses in the joint.

Methods

Fibroblasts derived from synovial membranes obtained during meniscus tear operations of otherwise

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