Adiponectin stimulates prostaglandin E2 production in rheumatoid arthritis synovial fibroblasts
β Scribed by Natsuko Kusunoki; Kanako Kitahara; Fumiaki Kojima; Nahoko Tanaka; Kaichi Kaneko; Hirahito Endo; Toru Suguro; Shinichi Kawai
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 256 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0004-3591
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The authors have shown that the interferon inducer, double-stranded polynucleotide, poly I poly C, and human interferon stimulate prostaglandin E (PGE) (1) and hyaluronic acid (HA) production (2) in human synovial fibroblast cultures and induce inflammation when injected into the rat joint ( 3 ) . A
## Abstract ## Objective Membraneβassociated prostaglandin E synthase (mPGES) is a recently identified terminal enzyme of the arachidonic acid cascade, which converts PGH~2~ to PGE~2~ in rheumatoid arthritis synovial fibroblasts (RASFs). This study was undertaken to investigate factors regulating
## Abstract The interferonβinducer, polyinosinate. Polycyctidylate [Poly (I). Poly (C)] stimulated both prostaglandin E (PGE) and hyaluronic acid (HA) production by human cultured synovial fibroblasts. Increased accumulation of PGE in the medium was noted within 3 hours of culture, while accumulati
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