Steroids. CXXXVI. 1 Synthesis of a New Class of Potent Cortical Hormones. 6α-Fluoro- and 6α,9α-Difluoro-16α-methylprednisolone and Related Steroids 2
✍ Scribed by Edwards, J. A.; Ringold, H. J.; Djerassi, Carl
- Book ID
- 127116408
- Publisher
- American Chemical Society
- Year
- 1960
- Tongue
- English
- Weight
- 689 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0002-7863
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## Incubation of 6u-fluoro-Reichstein's Compound 3'" (I) and its A'-analog (IV) with bovine adrenals followed by acetylation led to 6c4uorohydrocortisone acetate (II) and 6a-fluoroprednisolone acetate (III) respectively. Selenium dioxide oxidation of II also afforded III. Chromium trioxide oxidati
## A six-step synthesis of tritiated 6a, 9a-d~uoro-l6u-methyl-11~, 17u,21 -trihydroxypregna-l,4-diene-3,20-dione (5) and 6a,9a-di~?uoro-11 f3,16a,I 7aJI -tetrahydroxypregna-I ,4-diene-3,20-dione 16~7-aeetonide ( 7 ) from the appropriate A174?9(11)-3-keto intermediates is described. Isotope inco