✦ LIBER ✦
Steroids CCCI (1). Radiochemical syntheses. Part I. Preparation of tritiated 6α, 9α-difluoro cortical hormones
✍ Scribed by D. L. Wren; J. B. Siddall; J. A. Edwards
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- French
- Weight
- 473 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
A six-step synthesis of tritiated 6a, 9a-d~uoro-l6u-methyl-11~, 17u,21 -trihydroxypregna-l,4-diene-3,20-dione (5) and 6a,9a-di~?uoro-11 f3,16a,I 7aJI -tetrahydroxypregna-I ,4-diene-3,20-dione 16~7-aeetonide (
7
) from the appropriate A174?9(11)-3-keto intermediates is described. Isotope incorporation was achieved by selectively reducing the I,2 and 4,5-double bonds with tritium gas followed by regeneration of the A134-3-keto system by dehydrogenation with D. D.Q.