𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Steroid 5α-reductase inhibitors in androgen-dependent disorders

✍ Scribed by Georgianna S Harris; John W Kozarich

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
675 KB
Volume
1
Category
Article
ISSN
1367-5931

No coin nor oath required. For personal study only.

✦ Synopsis

Inhibition of the steroid 5alpha-reductases shows promise in the treatment of a number of androgen-dependent disorders, such as benign prostatic hyperplasia, male pattern baldness, and acne. The design of potent and isozyme-selective inhibitors has provided biologists and clinicians with important tools for elucidating complex androgen physiology, and has already resulted in the development of one marketed drug.

📜 SIMILAR VOLUMES

Steroidal nitrone inhibitors of 5α-reduc
Steroidal nitrone inhibitors of 5α-reductase
✍ Andrea J Robinson; Indawati DeLucca; Spencer Drummond; George A Boswell 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 106 KB

This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i

ChemInform Abstract: Steroidal Antiandro
ChemInform Abstract: Steroidal Antiandrogens and 5α-Reductase Inhibitors
✍ Eugene Bratoeff; Elena Ramirez; Eugenia Murillo; Gregoria Flores; Marisa Cabeza 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Pyrrolebutyric Acid
ChemInform Abstract: Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase.
✍ M. KATO; K. KOMODA; A. NAMERA; Y. SAKAI; S. OKADA; A. YAMADA; K. YOKOYAMA; E. MI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase. -A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities

Synthesis of carbon-14 and tritiated ste
Synthesis of carbon-14 and tritiated steroidal 5α-reductase inhibitors
✍ Arthur Y. L. Shu; J. Richard Heys 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 414 KB

## Abstract 17β‐[N‐(1,1‐Dimethylethyl)carbamoyl]androsta‐3,5‐diene‐4‐^14^C‐3‐carboxylic acid ([^14^C]SK&F 105657) was prepared __via__ a three‐step sequence (t‐butyl amidation, triflation and carbomethoxylation) starting from androst‐4‐en‐3‐one‐4‐^14^C‐17β‐carboxylic acid. Its A‐ring aromatic analo