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Stereospecific total synthesis of rac. 5α-pregnan-3β-ol-20-one

✍ Scribed by W. Nagata; T. Terasawa; T. Aoki

Publisher
Elsevier Science
Year
1963
Tongue
French
Weight
178 KB
Volume
4
Category
Article
ISSN
0040-4039

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✦ Synopsis

THE total synthesis of several steroids (1.2) has previously been reported from this laboratory.

In this communication a straightforward total synthesis of rec. 5a-preQnan-3~-ol-20-one (XIIIa) is reported.

'3 All melting points were measured on Kofler block and corrected. '

📜 SIMILAR VOLUMES

Synthesis of 5α-pregnane-3β,20α-diol and
Synthesis of 5α-pregnane-3β,20α-diol and of 5α-pregnane-3α,20α-diol labelled specifically at the 20β-position
✍ T. A. Baillie; J. E. Herz; J. Sjövall 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 241 KB 👁 1 views

## Abstract A convenient synthesis of 5α‐[20β‐^2^H]pregnane‐3α,20α‐diol and 5α‐[20β‐^2^H]pregnane‐3β,20α‐diol from 3β‐hydroxy‐5α‐pregn‐16‐en‐20‐one is described. The reaction products are characterized by combined gas chromatography‐mass spectrometry.