Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents
✍ Scribed by Scott Wieland; Nancy C. Lan; James D. Belluzzi; Larry Stein
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 893 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0033-3158
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## Abstract A convenient synthesis of 5α‐[20β‐^2^H]pregnane‐3α,20α‐diol and 5α‐[20β‐^2^H]pregnane‐3β,20α‐diol from 3β‐hydroxy‐5α‐pregn‐16‐en‐20‐one is described. The reaction products are characterized by combined gas chromatography‐mass spectrometry.
THE total synthesis of several steroids (1.2) has previously been reported from this laboratory. In this communication a straightforward total synthesis of rec. 5a-preQnan-3~-ol-20-one (XIIIa) is reported. '3 All melting points were measured on Kofler block and corrected. '