## Stereospecific Synthesis of Bicyclic Diaziridines: 4a-Chloro-; 4e,6a-and 4a,6e-Dichloro-5-methoxycarbonyl-1,6diazabicyclo[3.1.0]hexanes. -Amination of 3-chloro-1-pyrroline (I) with H 2 N-O-SO 3 H occurs predominantly from the anti side with respect to chlorine to afford diaziridine (II). Chlor
โฆ LIBER โฆ
Stereospecific synthesis of bicyclic diaziridines: 4a-chloro-; 4e,6a- and 4a,6e-dichloro-5-methoxycarbonyl-1,6-diazabicyclo[3.1.0]hexanes
โ Scribed by Sergey N. Denisenko; Paul Rademacher; Remir G. Kostyanovsky
- Book ID
- 111730048
- Publisher
- Royal Society of Chemistry
- Year
- 1998
- Tongue
- English
- Weight
- 175 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0959-9436
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A facile approach to pyrazolo [4,3-e][1,4] diazepin-5,8-diones andpyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepin-5,10-diones is reported. Strategy involved the utility of ฮฑ-amino acid as a three-atom segment in the construction of diazepine skeleton on the preformed pyrazole ring.