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Stereospecific reduction of 2,3-epoxybutanoic acid. Synthesis of (R,R)- and (S,S)-3-hydroxybutanoic-2-d acid and S-tert-butyl 3-acetoxythiobutanoate-2-d

✍ Scribed by Mohrig, Jerry R.; Vreede, Pieter J.; Schultz, Steve C.; Fierke, Carol A.


Book ID
126028989
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
570 KB
Volume
46
Category
Article
ISSN
0022-3263

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Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi