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Effective, High-Yielding, and Stereospecific Total Synthesis of d-erythro-(2R,3S)-Sphingosine from d-ribo-(2S,3S,4R)-Phytosphingosine

โœ Scribed by van den Berg, Richard J. B. H. N.; Korevaar, Cornelius G. N.; Overkleeft, Herman S.; van der Marel, Gijsbert A.; van Boom, Jacques H.


Book ID
111937132
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
101 KB
Volume
69
Category
Article
ISSN
0022-3263

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Novel, efficient and stereospecific synt
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The stereo-and regioselective elaboration of a bromohydrin from an olefinic precursor and Pummerer ene reaction for carbon carbon bond formation are the key steps in a novel and flexible synthesis of xylo-phytosphingosine and threo-sphingosine.