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Enantioselective synthesis of d-ribo-(2S,3S,4R)-C18-phytosphingosine using double stereodifferentiation
β Scribed by S.Vasudeva Naidu; Pradeep Kumar
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 124 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The first diastereoselective synthesis of L-xylo -(2R,3S,4S)-C 18 -phytosphingosine (1) has been achieved by double stereodifferentiation of enantiomerically enriched terminal olefin 14 using (DHQD) 2 -PHAL ligand in an asymmetric dihydroxylation with a diastereomeric ratio of 83:17. This phytosphin
d-Propoxyphene, first synthesized by Pohland and Sullivan (la), is a commonly used analgesic. Metabolism studies (2) on racemic N-methyl-14C propoxyphene (3) established that the major metabolic product is the N-demethylated compound. Analytical and metabolic studies performed on d-propoxyphene in t