5-Dcoxy-J,2-O-isopropylidene-S-C-(methoxyphenylphosphinyl)-~-O-~~thyl-n-D-ribofuranose (4) was prepared from 1,2-0-isopropylidene-3-O-methyl-a-D-ribo-pentodialdo-1,4-furanose by an addition reaction with methyl phenylphosphinate, followed by deoxygenation of the terminal HO-$H-P group of the adduct
✦ LIBER ✦
Asymmetric synthesis of (2S,3R) β-(4-F-3-NO2) phenyl serine, D-(R)-4-methoxy-3,5-bistbutyldimethylsiloxy phenylglycine and their assemblage to C-O-D ring of vancomycin
✍ Scribed by Jieping Zhu; Jean-Philippe Bouillon; Girij Pal Singh; Jacqueline Chastanet; René Bengelmans
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 220 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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## Treatment of methyl 5-deoxy-S-C-(diethoxyphosphinyl)-2.3-O-isopropylidene-p-D-ribofuranoside with sodium dihydrobis(2-methoxyethoxy)aluminate, followed by hydrogen peroxide, mineral acid, and hydrogen peroxide, gave 5deoxy-5-C-(hydroxyphosphinyl)-a,P-D-ribopyranoses in 40-45% overall yield. The