๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Stereoselective synthesis of the fully functionalized core fragment of terpentecin

โœ Scribed by Taotao Ling; Fatima Rivas; Emmanuel A. Theodorakis

Book ID
104252462
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
232 KB
Volume
43
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

A stereoselective synthesis of the core fragment 4 of terpentecin is presented. The five contiguous asymmetric centers of 4 were prepared from enone 8 via a sequence of steps highlighted by: oxygenation of the C6 center by epoxidation of enone 18, methylenation of the C8 carbonyl group of 20 by means of the Peterson olefination, stereoselective construction of the C8 center of 21 using homogeneous catalytic hydrogenation and stereoselective oxygenation of the C7 center.

๐Ÿ“œ SIMILAR VOLUMES

Stereoselective Synthesis of the Functio
Stereoselective Synthesis of the Functionalized C2โ€“C10 Fragment of Clavulactone
โœ Zuozhong ZHOU; Dong SUO; Zhenyu YANG; Lin CHEN; Taishan HU; Zhujun YAO ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 110 KB

A stereoselective synthesis of all functionalized C2-C10 fragment 13 of the antitumor marine natural product clavulactone was accomplished, starting from the commercially available 3-methylglutaric acid anhydride. Desymmetrization of 3-methylglutaric acid anhydride with (S)-ฮฑ-phenylethanamine was su