Stereoselective synthesis of the cytotoxic macrolide aspergillide B

✍ Scribed by Santiago Díaz-Oltra; César A. Angulo-Pachón; María N. Kneeteman; Juan Murga; Miguel Carda; J. Alberto Marco

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 274 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.04.026

✦ Synopsis

A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by means of the Yamaguchi procedure.