Reaction of the lithium e&ate of (-)7 with iodomethane provides a stereoselective synthesis of (2R,4S)-4-amino-2-methylpentanamide derivatives.
β¦ LIBER β¦
Stereoselective synthesis of isoquinoline derivatives from bicyclic lactam templates
β Scribed by Steven M. Allin; Darshan G. Vaidya; Stella L. James; James E. Allard; Timothy A.D. Smith; Vickie McKee; William P. Martin
- Book ID
- 104251046
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 107 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
We report a novel, facile and stereoselective approach to a tricyclic tetrahydroisoquinoline ring system from readily available, non-racemic, bicyclic lactam substrates.
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In this work, the usual 1,s-functionality distance of Robinson annulation products was transformed into the required 1,4-dicarbonyl distance. ') The C-atom numbering corresponds to the cinchonan numbering (see Fig. )