The synthesis of 13-azaprostacyclin methyl ester 13 in ten steps from the readily available 2-exo-bromo-3-endo-methoxybicyclx3.2.0]heptan-6one 1 is described. --Inhibition of platelet aggregation and vasodilation are two well recognised properties of prostacyclin and based on these effects it has g
Stereoselective synthesis of 13-dehydroxy-(14S)-hydroxyamphotericin B methyl ester
โ Scribed by William S. MacLachlan; Simon A. Readshaw
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 173 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A new methodology for performing aldol reactions with an excellent degree of enantio-and diastereoselectivity was developed employing (+)-(S,S)-pseudoephedrine as chiral auxiliary.
A novel carbinolammonium chloride has been synthesized as a possible intermediate in the biosynthetic conversion of the 13-methylprotoberberine alkaloid (+)-tetrahydrocorysamine to the benzophenanthridine alkaloids (+)-corynoline, (+)-14-epicorynoline, and the Bsecoprotoberberine alkaloid (+)-coryda
%Methyl -6-[3-( t r i f 1 uoromethyl ) phenyl 1-1,2,4-triazolo[4,3-b] p y r i d a z i n e ($), c u r r e n t l y being evaluated as a p o t e n t i a l anxiol y t i c agent was synthesized, l a b e l e d w i t h carbon-14 i n the 3p o s i t i o n o f t h e t r i a z o l o nucleus. i n 67% radiochemi