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Stereoselective synthesis of a 13-azaprostacyclin methyl ester

✍ Scribed by Eric W. Collington; Harry Finch; Christopher J. Wallis

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
183 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of 13-azaprostacyclin methyl ester 13 in ten steps from the readily available 2-exo-bromo-3-endo-methoxybicyclx3.2.0]heptan-6one 1 is described.

--Inhibition of platelet aggregation and vasodilation are two well recognised properties of prostacyclin and based on these effects it has generated immense interest in the fields of thrombosis and vascular disease.

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