Stereoselective synthesis of unsaturated very long chain fatty acid methyl esters

✍ Scribed by Julie Defretin; Jairo Saez; Xavier Franck; Reynald Hocquemiller; Bruno Figadère

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 222 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00666-8

✦ Synopsis

Very long chain fatty acids are isolated from many different natural sources. However their unsaturated and particularly their diunsaturated derivatives with a k n,"+4 pattern are almost exclusively encountered in marine organisms, until we fimnd some derivatives in the botanical family of the Annonaceae. In this letter we present a very efficient synthesis of this family of products based Ola the new transition metalcatalyzed coupling reaction between an organomagnesium reagent and a fu,actionalized vinyl bromide.