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Stereoselective synthesis and solvolytic behavior of the isomeric 7-dehydrocholesterol 5,6-oxides

✍ Scribed by Michaud, Dennis P.; Nashed, Nashaat T.; Jerina, Donald M.


Book ID
121322811
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
749 KB
Volume
50
Category
Article
ISSN
0022-3263

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Synthesis of tritium labelled 7-dehydroc
✍ Dennis P. Michaud; Nashaat T. Nashed; Donald M. Jerina πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 French βš– 235 KB

We report the synthesis of tritiated 7-dehydrocholesterol 5@,6B-oxide in high specific activity. Oxidation of 7a-bromocholesterol 5B16B-oxide to the 3-keto epoxide followed by borotritide reduction, in a special buffer-organic solvent system to minimize undesired rearrangement, regenerated the 3B-hy