𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of tritium labelled 7-dehydrocholesterol 5β,6β-oxide

✍ Scribed by Dennis P. Michaud; Nashaat T. Nashed; Donald M. Jerina

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
235 KB
Volume
23
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

We report the synthesis of tritiated 7-dehydrocholesterol 5@,6B-oxide in high specific activity. Oxidation of 7a-bromocholesterol 5B16B-oxide to the 3-keto epoxide followed by borotritide reduction, in a special buffer-organic solvent system to minimize undesired rearrangement, regenerated the 3B-hydroxyl group. Base-assisted elimination produced the title compound.

📜 SIMILAR VOLUMES

Synthesis of labelled ecdysone precursor
Synthesis of labelled ecdysone precursors: Part I-tritium labelled (3H4-22, 23,24,25)-3β, 14α-dihydroxy-5β-cholest-7-en-6-one
✍ T. Haag; C. Hetru; Y. Nakatani; B. Luu; L. Pichat; M. Audinot; M. Meister 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 365 KB

has b e e n p r e p a r e d u s i n g a p r e c u r s o r which p e r m i t s r a p i d a n d e a s y l a b e l l i n g . T h i s compound is c o n v e r t e d t o e c d y s o n e under i n v i t r o c o n d i t i o n s by i n s e c t p r o t h o r a c i c g l a n d s , a w e l l known s i t e of e

Synthesis of 6β,7β-nitromethylene steroi
Synthesis of 6β,7β-nitromethylene steroids
✍ Elliot L. Shapiro; Geoffrey Page; Lois Weber; Margaret J. Gentles; Andrew T. McP 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 206 KB
Synthesis of tritium labelled metaramino
Synthesis of tritium labelled metaraminol, α- methylnoradrenaline and their corresponding β- desoxyderivatives
✍ G. Hallhagen; B. Waldeck 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 French ⚖ 362 KB

m-hydroxy-u-oximinopropiophenone was hydrogenated by tritium gas in the presence of Pd on carbon catalyst. The crude product was chromatographed on a cation-exchange column. Two major peaks were obtained. Subsequent radio-paper chromatography revealed that these peaks were identical with metaraminol