We report the synthesis of tritiated 7-dehydrocholesterol 5@,6B-oxide in high specific activity. Oxidation of 7a-bromocholesterol 5B16B-oxide to the 3-keto epoxide followed by borotritide reduction, in a special buffer-organic solvent system to minimize undesired rearrangement, regenerated the 3B-hy
Synthesis of 3β-fluoro derivatives of 7-dehydrocholesterol and of ergosterol
✍ Scribed by R. I. Yakhimovich; N. F. Fursaeva; V. E. Pashinnik
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 491 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0009-3130
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Optically active 3-fluoro+lactam (1) was stereoselectively synthesized by the ketene-imine condensation method. Use of (1) in alkylation and aldol reactions resulted in the stereoselective formation of ( 2) and ( 3) respectively, but the control of the hydroxylated stereocenter was not possible in
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