Ring-isomeric change in isoflavones: : Synthesis of 5,7-dimethoxy-6-hydroxyisoflavone, muningin and 5,7-dihydroxy-6-methoxyisoflavone
โ Scribed by M.L. Dhar; T.R. Seshadri
- Publisher
- Elsevier Science
- Year
- 1959
- Tongue
- French
- Weight
- 46 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The above mentioned compounds have been prepared by methods involving isomeric change from the more readily available 5,7,&substituted isoflavones.
๐ SIMILAR VOLUMES
OF the twenty-one known natural isoflavones,' three, tectorigenin, irigenin, and caviunin, are derivatives of 5,7-dihydroxy-6-methoqyisoflevone. This particular orientation of substituents makes a direct synthesis difficult, but a method, which we believe to be general, for the synthesis of such iso
So far one has only succeded in synthetising 5.7~dihydroxy-6-methoxyflavonea bearing not more than one substituent on the phenyl side Aain /B-ring/ l-9. b tried to solve this problem by alkaline ring isomerization 10-12.
Methylglyoxal (2-oxopropanal) may be assayed tn chemtcal and tuologlcal systems by denvatlsatlon wtth 1,2& ammo-4,Sdtmethoxybenzene to form 6,7dlmethoxy-2-methylqumoxabne Methods are described to produce 1,2-cbammo-4,5-d~methoxylxznzene dlhydrochlonde (the denvatwng agent), 6,7-dlmethoxy-2-methylqwx