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Synthesis and chromatography of 1,2-diamino-4,5-dimethoxybenzene, 6,7-dimethoxy-2-methylquinoxaline and 6,7-dimethoxy-2,3-dimethylquinoxaline for use in a liquid chromatographic fluorimetric assay of methylglyoxal

✍ Scribed by Antony C. McLellan; Paul J. Thornalley

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 557 KB
Volume: 263
Category: Article
ISSN: 0003-2670
DOI: 10.1016/0003-2670(92)85435-9

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✦ Synopsis

Methylglyoxal (2-oxopropanal) may be assayed tn chemtcal and tuologlcal systems by denvatlsatlon wtth 1,2& ammo-4,Sdtmethoxybenzene to form 6,7dlmethoxy-2-methylqumoxabne Methods are described to produce 1,2-cbammo-4,5-d~methoxylxznzene dlhydrochlonde (the denvatwng agent), 6,7-dlmethoxy-2-methylqwxxalme (the methylglyoxal adduct) and 6,7-dunethoxy-2,3-dunethylqulnoxalme (an mternal standard) hquld chromatography data of the methylglyoxal adduct and Internal standard wth spectrophotometnc and fluonmetnc detection arc presented The punty of these compounds was smtable for their use m assay, recovery expenments and Internal standardlsanon m the analyw of trace amounts of methylglyoxal

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