The absolute configurations of enantiomeric 7-bromo-12lpethylbenz[a]anthracene cis 5,6-dihydrodiols (3) were determined by exciton chirality circular dichroism method, The absolute configurations of enantiomeric 12-methylbenz[a]anthracene c&-5,6-dihydrodiols (1) were determined by debromination of e
Stereoselective syn epoxidation of the dihydrodiols of dibenz[a,h] anthracene and 7-methylbenz[a] anthracene
β Scribed by Hongmee Lee; Ronald G. Harvey
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 238 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The racemic anti-dihydrodiol epoxide of 7-methylbenz[a]anthracene preferentially induced mutations at G.C base pairs in the pS189 shuttle vector. Mutations were not randomly distributed throughout the supF target gene, but were concentrated at five hotspots. The hotspots for this agent did not corre
Stereospecific syntheses of the anti-and syn-diol epoxides of 7-and 12-methylbenz[a]anthracene, suspected as active metabolites of the parent PAHs but previously thought to be too chemically reactive and unstable to isolate, are described and the pure compounds are shown to be moderately stable.
Numerous lines of evidence have now implicated 7,8-diol-9,10-epoxides as metabolically formed ultimate carcinogens from the environmental contaminant benzo[alpyrene. ly2 In an attempt to generalize the concept of diol epoxides3 as ultimate carcinogens, we have attempted to predict which of the sever
T r i t i u m l a b e l l e d K-region oxides o f pyrene, benzoCalpyrene and d i b e n z [ G ] a n t h r a c e n e have been prepared by c y c l i z a t i o n o f the corresponding t r a n s -d i h y d r o d i o l s which were obtained by r e d u c t i o n o f K-region quinones w i t h sodium b o r
## Abstract The metabolism and consequent macromolecular binding of dibenz(a,c)anthracene and dibenz(a,h) anthracene by mouse embryo cells in culture was compared at approximately equal, low doses of hydrocarbon in the medium. Both hydrocarbons were metabolized more slowly than other hydrocarbons t