## Abstract An enantioselective highβperformance liquid chromatographic method for the analysis of carvedilol in plasma and urine was developed and validated using (β)βmenthyl chloroformate (MCF) as a derivatizing reagent. Chloroform was used for extraction, and analysis was performed by HPLC on a
Stereoselective analysis of nadolol in human plasma
β Scribed by N. R. Srinivas; W. C. Shyu; V. R. Shah; D. A. Campbell; R. H. Barbhaiya
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 266 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0269-3879
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and β£1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 Β± 5.5%, 83.8 Β± 5.2%, and 75
## Abstract Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20β30 ng ml^β1^ 1β2 h after administration; 72 h after administration, plasma concentrat
A quantitative method was developed and validated for rapid and sensitive analysis of cimetidine in human plasma. The method involved the use of liquid chromatography (LC) coupled with atmospheric pressure chemical ionization (APCI) and selected reaction monitoring (SRM) mass spectrometry (MS). A ci
Enzymatic hydrolysis with β€-glucuronidase/sulfatase was used for the enantioselective determination of N-hydroxymexiletine glucuronide in plasma for pharmacokinetic studies. N-Hydroxymexiletine glucuronide was determined as the quantity of mexiletine released by hydrolysis (difference between the en