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High-performance liquid chromatographic assay for the quantitation of nadolol in human plasma using fluorescence detection

✍ Scribed by Nuggehally R. Srinivas; Wen Chyi Shyu; Vinod R. Shah; Dale A. Campbell; Rashmi H. Barbhaiya

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
368 KB
Volume
9
Category
Article
ISSN
0269-3879

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A simple, reliable HPLC method using fluorescence detection (excitation 307 and emission 483 nm) was developed and validated for simultaneous quantitation of zopiclone and its metabolite desmethylzopiclone in human plasma. Following a single-step liquid-liquid extraction, the analytes and internal s