✦ LIBER ✦

Plasma levels of chlorodesmethyldiazepam in humans

✍ Scribed by L. Dal Bo; F. Marcucci; E. Mussini; D. Perbellini; A. Castellani; P. Fresia

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 199 KB
Volume: 1
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510010306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20–30 ng ml^−1^ 1–2 h after administration; 72 h after administration, plasma concentrations are still measurable (5 ng ml^−1^).

The analytical method involved a single extraction of I from the plasma into benzene followed by centrifugation, evaporation, and gas‐chromatographic analysis of the samples.

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