Plasma levels of ethaverine after oral administration to humans

✍ Scribed by Marvin C. Meyer; Gursharan Raghow; Arthur B. Straughn

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 215 KB
• Volume: 4
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510040412

✦ Synopsis

Fourteen healthy human subjects received a 200 mg oral dose of ethaverine hydrochloride as an elixir. Blood samples were obtained for 12h after dosing. Plasma ethaverine concentrations were determined using a paired-ion, reversed-phase high performance liquid chromatographic method. Individual plasma concentration-time profiles were fitted to a two-compartment model with first-order absorption. The ethaverine was rapidly absorbed, based on a time of maximum plasma concentration of 0.75 h, a time-lag of 8.4min, and an apparent first-order absorption half-life of 86min. The mean terminal elimination half-life was 3.3 h.

KEY WORDS Ethaverine Human pharmacokinetics Oral absorption HPLC assay

subject^,^ little has been published regarding the disposition of ethaverine.

Ethaverine HCI dosage forms are marketed as 100 and 150mg immediaterelease tablets and controlled-release capsules. This study was designed to investigate the absorption and elimination kinetics of ethaverine in fourteen subjects, following the oral administration of 200 mg of ethaverine hydrochloride given as an elixir. *To whom inquiries should be directed.