𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetics of ketotiffn after oral administration to healthy male subjects

✍ Scribed by Dr A. Grahnén; A. Lönnebo; O. Beck; S-Å Eckernäs; B. Dahlström; B. Lindström

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
406 KB
Volume
13
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The pharmacokinetics of 2 mg ketotifen from four different oral dosage forms were examined in two randomized, balanced cross‐over studies. Forty healthy male subjects participated. Each of 20 subjects received two capsule formulations and each of the other 20 subjects received two syrup formulations. Ketotifen concentrations in plasma were determined by a modified GC—MS method. The limit of quantitation was 40 pg ml^−1^. Inter‐day precision and accuracy calculated from quality control samples were 16·3 per cent (−1·9 per cent), 19·8 per cent (+4·5 per cent) and 23·6 per cent (+ 5·9 per cent) at plasma concentration levels of 86 (n = 18), 215 (n = 19) and 343 (n = 18) pg ml^−1^, respectively. Ketotifen was rapidly absorbed from all dosage forms reaching C~max~ in the order of 400 pg ml^−1^ after the syrup formulations and 300 pg ml^−1^ after the capsule formulations within 2 to 4 h. The syrup formulations showed a significantly more rapid rate of absorption as assessed by T~max~. No significant differences in extent of absorption between dosage forms were observed. The terminal elimination half‐life of ketotifen varied between subjects from 7 to 27 hours with a mean of about 12 h. The minor pharmacokinetic difference between dosage forms observed in this study is unlikely to be of clinical significance.

📜 SIMILAR VOLUMES

Comparative pharmacokinetics of midazola
Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration
✍ R. Jochemsen; P. A. Van Rijn; T. G. M. Hazelzet; C. J. Van Boxtel; D. D. Breimer 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 397 KB

The pharmacokinetics of oral midazolam (Dormicum@, 15 mg) and loprazolam (Dormonoct@, 1 mg) were studied in eight healthy young volunteers in a cross-over design. Plasma concentrations of midazolam were measured with a gas chromatographic method and loprazolam concentrations were determined by a rad

Pharmacokinetics of fluvoxamine maleate
Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects
✍ M. H. De Vries; J. Van Harten; P. Van Bemmel; M. Raghoebar 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB 👁 2 views

The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100mg fluvoxamine maleate was studied in a three-way cross-over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For doseproportionality, AUC, and C,-dose relationships were evalu

Preliminary pharmacokinetic study of ibu
Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers
✍ Gianfranco Fornasini; Nunzia Monti; Giandomenico Brogin; Maddalena Gallina; Mari 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB 👁 2 views

The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (designated trade name: Spedifen), 400 mg (-)R-ibuprofen

Human dolasetron pharmacokinetics: II Ab
Human dolasetron pharmacokinetics: II Absorption and disposition following single-dose oral administration to normal male subjects
✍ Harold Boxenbaum; Todd Gillespie; Kathleen Heck; William Hahne 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 485 KB 👁 1 views

## Abstract Dolasetron is a 5‐hydroxytryptamine antagonist active at type III receptors; it is presently undergoing clinical evaluation for the reduction/prevention of cancer chemotherapyinduced nausea and vomiting. A previous study demonstrated that following intravenous administration to healthy

Pharmacokinetics of teicoplanin upon mul
Pharmacokinetics of teicoplanin upon multiple dose intravenous administration to normal healthy male volunteers
✍ Gary A. Thompson; Jacquelyn A. Smithers; Michael T. Kenny; Jacqueline K. Dulwort 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB 👁 1 views

## Abstract Teicoplanin pharmacokinetics were investigated upon multiple dose intravenous administration of 6 and 12 mg kg^−1^ in 10 normal, healthy, male volunteers, using a two‐period, randomized, crossover design; six subjects completed both periods. On day 1, 6 or 12 mg kg^−1^ was administered