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Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects

✍ Scribed by M. H. De Vries; J. Van Harten; P. Van Bemmel; M. Raghoebar

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 286 KB
Volume: 14
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510140403

No coin nor oath required. For personal study only.

✦ Synopsis

The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100mg fluvoxamine maleate was studied in a three-way cross-over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For doseproportionality, AUC, and C,-dose relationships were evaluated by linear regression. Plasma concentrations increased in a linear dose-dependent manner in the dose range between 25 and 1OOmg; I, and T,, showed no significant differences among treatments. Fluvoxamine was well tolerated.

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