𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetics of repeated single oral doses of enalapril maleate (mk-421) in normal volunteers

✍ Scribed by Dr. Alice E. Till; Hector J. Gomez; Martin Hichens; James A. Bolognese; W. R. McNabb; B. A. Brooks; F. Noormohamed; A. F. Lant

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
372 KB
Volume
5
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy volunteers as a capsule containing 10 mg of the maleate salt, every 24h for eight doses. Serum profiles show little accumulation of enalaprilat following eight daily doses of enalapril maleate. An average effective half-life for accumulation of approximately 11 h was calculated from urine data. Comparison of observed 24-h urinary recoveries of enalaprilat to predicted steady-state recovery indicates that an 'average' steady state for enalaprilat is attained by the third or fourth dose of enalapril maleate. Statistical comparison of daily urinary recoveries, as well as Cmin values for enalaprilat, confirm this. Observed fluctuations in serum and urine data during apparent steady state suggest some day-to-day variability in the absorption of enalapril maleate and/or its hydrolysis to enalaprilat. An accumulation ratio of 1.3 for enalaprilat was calculated from the predicted steady-state urinary recovery and observed urinary recovery for dose one.

πŸ“œ SIMILAR VOLUMES

Pharmacokinetics of fluvoxamine maleate
Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects
✍ M. H. De Vries; J. Van Harten; P. Van Bemmel; M. Raghoebar πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 286 KB πŸ‘ 1 views

The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100mg fluvoxamine maleate was studied in a three-way cross-over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For doseproportionality, AUC, and C,-dose relationships were evalu

Single dose pharmacokinetics of HEPP, a
Single dose pharmacokinetics of HEPP, a new anticonvulsant in normal healthy volunteers
✍ Dinora F. GonzΓ‘lez-Esquivel; Francisco Rubio-Donnadieu; Guillermo Carvajal S.; H πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 128 KB πŸ‘ 2 views

The pharmacokinetics and the dose proportionality of a new anticonvulsant compound, HEPP (D,L-3-hydroxy-3-ethyl-3-phenylpropionamide) was studied in healthy male volunteers as part of the pharmacological evaluation for new drugs. Study was performed administering doses of 250, 375, 500 and 625 mg of

Single- and multiple-dose pharmacokineti
Single- and multiple-dose pharmacokinetics of oral dolasetron and its active metabolites in healthy volunteers: part 2
✍ Dan C. Dimmitt; Youn Sung Choo; Lorene A. Martin; Thangam Arumugham; William F. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 132 KB πŸ‘ 2 views

The single-and multiple-dose pharmacokinetics and dose-proportionality of oral dolasetron and its active metabolites over the therapeutic dose range was investigated in 18 healthy men. In an open-label, randomized, complete three-way crossover design, each subject received three separate doses: 50,