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Stereoisomers of Cyclic Urea HIV-1 Protease Inhibitors: Synthesis and Binding Affinities

โœ Scribed by Kaltenbach, Robert F.; Nugiel, David A.; Lam, Patrick Y. S.; Klabe, Ronald M.; Seitz, Steven P.


Book ID
120549669
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
161 KB
Volume
41
Category
Article
ISSN
0022-2623

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Synthesis of unsymmetric cyclic urea dio
โœ Benjamin R.P. Stone; Gregory D. Harris; Reginald O. Cann; Thomas E. Smyser; Pat ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 200 KB

Unsymmetric cyclic urea diols of general structure 1 can be prepared either via an isourea derived from the symmetric diamine 2 or by the selective removal of a benzyl group from certain symmetric cyclic ureas 8, employing dissolving metal reduction.