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Stereocontrolled synthesis of the spiroketal unit of 22,23-Dihydroavermectin B1b.

✍ Scribed by J. Ardisson; J.P. Férézou; M. Julia; L. Lenglet; A. Pancrazi

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
271 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis

A diastereocontrolled synthesis of the spiroketal sub-unit of 22,23-dihydroavermectin B has been developed using a formal pentane z,& 2" -double condensation at both ends of zone 3 with intermediate formation of the ketal 5.

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