Synthesis of the spiroketal fragment of avermectin B1b
โ Scribed by Michael T. Crimmins; Rosemary O'Mahony
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 220 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Interesting reactivitics have baen observed upon reaction of epoxy-spiroketal 1 with a variety of dimethyl-aluminum sulfides, and are compared with results obtained upon reaction of the same epoxide 1 with diethyl alu&um cyanide. These chemical modifications provide access to novel avermeuin Bb anal
A diastereocontrolled synthesis of the spiroketal sub-unit of 22,23-dihydroavermectin B has been developed using a formal pentane z,& 2" -double condensation at both ends of zone 3 with intermediate formation of the ketal 5.
A new method for the synthesis of unsaturated spiroacetals from 2-benzenesulphonyltetmhydropyrans is presented IH and 13C studies of one of these spiroacetals led to a reassignment of some 1H and 13C resonances of Avermectin B la.