An enantiospecific synthesis of the spiroketal portion of avermectin B1a
β Scribed by Christina M.J. Fox; Roger N. Hiner; Ulhas Warrier; James D. White
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 215 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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A chiral synthesis of the spiroketal moiety of avermectin A2b has been accomplished in 14 steps from (3S(R),&R(S))-3,5-dimethyl-1-hexen-4-01. The avermectins and the structurally related milbemycins have attracted considerable