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Enantiospecific synthesis of the spiroacetal unit of avermectin b1a

✍ Scribed by Masahiro Hirama; Takeshi Nakamine; Shô Itô

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
270 KB
Volume
27
Category
Article
ISSN
0040-4039

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A new method for the synthesis of unsaturated spiroacetals from 2-benzenesulphonyltetmhydropyrans is presented IH and 13C studies of one of these spiroacetals led to a reassignment of some 1H and 13C resonances of Avermectin B la.

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gummary -An efficient oxidative degradation of avermectin Bla affording suitably functionalized Cl-C10 and Cll-Czs segments is reported. Recently, we reported a stereospecific total synthesis' of the Cll-C2s segment of the potent anthelmintic agent (+I-avermectin Bla,' culminating in the synthesis