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Synthesis and Configuration of Some Hydroxymilbemycin Derivatives Including 22,23-Dihydroavermectin B1b Aglycone

✍ Scribed by Bruno Frei; Philip Huxley; Peter Maienfisch; Hari Babu Mereyala; Günther Rist; Anthony C. O'Sullivan

Publisher: John Wiley and Sons
Year: 1990
Tongue: German
Weight: 878 KB
Volume: 73
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19900730713

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✦ Synopsis

In toluene as solvent, the azidoalcohol was formed [lza].

HELVETICA CHIMICA ACTA Scheme 1

Vo1. 73 (1990) 1907

Oxidation of the 13a -hydroxy derivatives 15A and 15D with PDC in DMF afforded the ketones 14A and 14D in good yield [6b].

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