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Stereocontrolled synthesis of the Prelog-Djerassi lactone

✍ Scribed by White, James D.; Fukuyama, Yoshiyasu


Book ID
121412741
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
408 KB
Volume
101
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES


Total synthesis of (+)-prelog-djerassi l
✍ Minoru Isobe; Yoshiyasu Ichikawa; Toshio Goto πŸ“‚ Article πŸ“… 1981 πŸ› Elsevier Science 🌐 French βš– 203 KB

Optically active Prelog-Djerassi Lactonic Acid i was synthesized from D-glucal; the crucial point being the elaboration of the carboxylic group as shown in eq. 1 and 2 which involve the sequential process [i] asymmetric addition of methyl anion onto the hetero-olefin 2, [ii] trapping

A synthesis of (+)-Prelog-Djerassi Lacto
✍ Steven D. Hiscock; Peter B. Hitchcock; Philip J. Parsons πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 852 KB

A new approach to the synthesis of Prelog-Djerassi Lactonic acid (1) is reported. A key step in this synthesis involves an lreland-Claisen rearrangement/silicon-mediated fragmentation sequence to provide the carbon framework in (1).