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A synthesis of (+)-Prelog-Djerassi Lactonic acid

✍ Scribed by Steven D. Hiscock; Peter B. Hitchcock; Philip J. Parsons

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 852 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00676-0

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✦ Synopsis

A new approach to the synthesis of Prelog-Djerassi Lactonic acid (1) is reported. A key step in this synthesis involves an lreland-Claisen rearrangement/silicon-mediated fragmentation sequence to provide the carbon framework in (1).

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