Stereocontrolled synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline derivatives via chromium tricarbonyl methodologies
β Scribed by Stephen G. Davies
- Book ID
- 103228569
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 657 KB
- Volume
- 400
- Category
- Article
- ISSN
- 0022-328X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The synthesis of __N__βmethylβ4βpyridylβ1,2,3,4βtetrahydroisoquinolines **(6a,b,c)** was achieved __via__ a PictetβSpengler cyclization of an activated amino group derivatized in a carbamate form. The obtained compounds have been designed as potential serotonin analogs.
A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-earboxylic acid derivatives from ot,tx'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.