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Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Acid Derivatives via Ugi Reactions.

โœ Scribed by Ildiko Schuster; Anita Sztojkov-Ivanov; Laszlo Lazar; Ferenc Fueloep

Publisher
John Wiley and Sons
Year
2007
Weight
25 KB
Volume
38
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

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Synthesis of 1,2,3,4-Tetrahydroisoquinol
Synthesis of 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Tic) Derivatives by Cycloaddition Approaches
โœ Sambasivarao Kotha; Nampally Sreenivasachary ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 396 KB ๐Ÿ‘ 1 views

A new and general synthetic methodology for the preparation of functionalized 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives by a cycloaddition strategy is described. The synthesis of various enyne building blocks 12, 13, 21, and 22 containing an ฮฑ-amino acid moiety using Schiff base 8