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Stereocontrolled synthesis of (E,E,E)-chlorotrienes: Efficient intermediates for the construction of all E conjugated polyenes

✍ Scribed by Benoit Crousse; Mouâd Alami; Gérard Linstrumelle

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
240 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Stereoselective reduction of conjugated homopropargylic alcohols 1 followed by an elimination reaction, allows an efficient approach to stereodefined (E,E,E)-chlorotrienes. The interest of these chlorotrienes was illustrated by a stereocontrolled synthesis of navenone B and all E conjugated polyenes (tdenes, tetraenes and hexaenes).

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