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Efficient Two-Step Synthesis of Methylphytylbenzoquinones: Precursor Intermediates in the Biosynthesis of Vitamin E.

✍ Scribed by Satyamaheshwar Peddibhotla; Zigang Cheng; Dean DellaPenna; Jetze J. Tepe


Publisher
John Wiley and Sons
Year
2003
Weight
51 KB
Volume
34
Category
Article
ISSN
0931-7597

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Efficient Enantioselective Synthesis of
✍ Tietze, Lutz F. ;GΓΆrlitzer, Jochen πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 481 KB

Enantioselective bishydroxylation of the protected hydroxymethyl enynes 7a-d and 8a, b, which are easily obtained from commercially available 5 and 6, gave the triol derivatives 9a-d and l l a , b in good yields and moderate to high enantiomeric excess. Palladium-catalyzed coupling of 9a-d and l l a