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A highly efficient practical method for the synthesis of chiral polyhydroxy-(E,E)-1-chlorodienols and (E)-5-hydroxy enynes

✍ Scribed by J.S. Yadav; D.K. Barma; Dinah Dutta


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
179 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


An efficient protocol for the synthesis of chiral polyhydroxy-(E, E)-l-chlorodianols and (E)-5-hydroxy enynes from chiral 4,5-epoxy wdns allyl chlorides and 4,5-O-isopropylidene allyl chlorides is described by using stoichiometric amount of LiNH 2 or LDA in HMPA : THF (i : 5) useful in the synthesis of biologically active natural products.


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