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Stereocontrolled syntheses of 24(S),25-epoxycholesterol and related oxysterols for studies on the activation of LXR receptors

โœ Scribed by E.J. Corey; Michael J. Grogan


Book ID
104260314
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
193 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Efficient syntheses are described of desmosterol ( 4), the corresponding 24(S),25 epoxide ( 6) and various analogs of 6 for evaluation as ligands and functional activators of LXR receptors.


๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Stereocontrolled Sy
โœ E. J. Corey; Michael J. Grogan ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 37 KB

Stereocontrolled Syntheses of 24(S),25-Epoxycholesterol and Related Oxysterols for Studies on the Activation of LXR Receptors. -The title epoxide (IV) and derivatives thereof such as (V) and (VII) are prepared as interesting ligands and functional activators of LXR receptors. It is noteworthy that (

Simple, stereocontrolled syntheses of 24
โœ E.J. Corey; Michael J. Grogan ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 119 KB

Described herein are stereocontrolled syntheses of a series of sidechain oxygenated cholesterols for the study of binding and activation of nuclear receptors of the LXR family.